Breakthrough Non-narcotic Peptide Analgesic

The discovery phase has been over 25 years.
Now Preclinical study is 100% completed.

About

ANODYNAL® is painkiller for various methods of parenteral administration in a wide range of nociceptive and neuropathic pains.

No risk of drug addiction

which opioids has

No side-effect and toxicity

which NSAIDs has

No specific disadvantages

of full-size calcitonin molecule

How It Works

Possible drug form is nasal drops.

1

Chemical Structure

Synthetic analogue of the salmon calcitonin molecule fragment, which retains the analgesic activity of the full-size molecule.
It was selected and patented 288 variants of peptide sequences differing most stability and analgesic effectiveness (Patent "Synthetic peptides wtih a non-narcotic type of analgesic effect", WO2013141750A1).
2

Mechanism of action

The analgesic effect of ANODYNAL® is associated with a specific binding of a clathrin heavy chain.
Inhibition of clathrin-mediated endocytosis (CME) by clathrin blockage leads to irregular recycling of pain receptors in the postsynaptic vesicular cycle, which results in the analgesic effect.
This innovative mechanism of ANODYNAL® action has been patented (Patent "Specific peptide inhibitors of clathrin" WO2018186770A1).
3

Сomparison with other analgesics

The analgesic effect of ANODYNAL® is comparable to morphine and higher than that of ketorolac tromethamine, which is significantly superior to other NSAIDs, at doses 1000 times less and cost 3 times less.
Source: Arkady M Kotin, Maksim O Emelyanov and Oleg A Kotin «Low-molecular synthetic peptides with non-narcotic type of analgesia: comparative study and mechanism of analgesic activity», Molecular Pain, 2019, Volume 15: 1–13.

Opioid epidemic: key facts

  • Beginning in the 1980s, prescription opioids like oxycodone and hydrocodone were heavily marketed as a treatment for pain, and at the time, the risk of addiction to these substances was downplayed.
  • Opioid prescriptions nearly tripled between 1991 and 2011.
  • In 2015, nearly 100 million Americans were prescribed painkillers by their doctor.
  • 70 K opioid drug overdose deaths were registered in 2017 in the US.
  • Now drug overdoses are the leading cause of death for Americans under the age of 50, who are now more likely to die from a drug overdose than from car accidents or firearms.

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