Breakthrough Non-narcotic Peptide Painkiller
The discovery phase has been over 25 years.
Now Preclinical study is 100% completed.
The minimal fragment of a salmon calcitonin molecule that retains the analgesic activity of the full-size molecule
Chemical Structure
The most active of all known calcitonins is the full-length salmon calcitonin molecule. However, the use of a full-sized salmon calcitonin molecule for analgesia is limited due to its hormonal and antigenic properties and relatively high cost.
The authors have developed synthetic analogs of the salmon calcitonin molecule fragment sCТ16-21 (Leu-His-Lys-Leu-Gln-Thr), which retains the analgesic activity of the full-size molecule and do not have the above-mentioned disadvantages of a full-sized salmon calcitonin molecule. The whole family of synthetic low-molecular peptides, characterized by greater analgesic stability and effectiveness than the natural sequence, was produced by modifying the natural sequence sCT16-21.
This took more than 25 years.
Patents for synthetic peptides with a non-narcotic type of analgesic effect were obtained in Canada (CA 2.867.994), Europe (EU 2.848.629), Indonesia (ID P000053884), Russia (RU 2.508.295), USA (US 9.260 482) and Japan (JP 6.118.392).
Patent RU 2.508.295 was included in the list of “100 best inventions of Russia”, 2015.
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